![]() ![]() He said: “Autologous hematopoietic stem cell transplantation has been shown to be highly effective in stabilising, and even reversing disability, in certain patients with multiple sclerosis.” Credit: ITV GranadaĬhief trial investigator Prof John Snowden, a Consultant Haematologist at Sheffield Teaching Hospitals, said the study may also provide insights into immune system abnormalities that cause the disease. In MS, the immune system attacks the nerves, causing inflammation that affects the brain and spinal cord. Researchers say the £2.3 million study could soon lead to patients with aggressive MS being offered the transplant as a first-line treatment, instead of only when other treatments have failed. ![]() The world-first StarMS study, which has two specialist units in Liverpool and Salford, could offer new hope for people with aggressive forms of MS. It is currently incurable, and until recently, treatment has mainly used drugs that reduce the worst symptoms but do not halt the disease. It affects 100,000 Brits, and can lead to life in a wheelchair. Stem cells are used to repopulate the bone marrow to make new cells, which “reboots” the immune system. Credit: ITV GranadaĪutologous hematopoietic stem cell transplantation, or AHSCT, involves harvesting the patients’ blood and bone marrow stem cells before stripping the body’s immune system using chemotherapy. He says the transplant was life changing. ![]() James Coates was diagnosed with MS in 2011. "Now I can look forward to my future whereas beforehand I used to dread what the future held for me." "I am 99% sure I would be in a wheelchair full term, if not worse. James said: "I dread to think what condition I would be in if I hadn't had the transplant. He was accepted and had the transplant six and a half years ago. "It was the uncertainty of how the future was going to be that was the frightening thing."īut his wife Alison refused to give up hope and found out about a groundbreaking stem cell transplant trial. "I didn't know if I was going to get a new symptom this week or next week or if my current symptoms were going to get worse and if they were - how worse," the dad-of-two said. James Coates from Tarleton in Lancashire, was diagnosed with multiple sclerosis (MS) in 2011 after problems walking, facial numbness and cognitive issues.įollowing his diagnosis, any plans he'd had were put on hold, he said. Consumers should be cautious of any clinics, including regenerative medicine clinics, or health care providers, including physicians, chiropractors, or nurses, that advertise or offer any of these products," Kempler said.A man with multiple sclerosis says he has been given his future back after he underwent a pioneering stem cell transplant. Unproven/unapproved stem cell therapies can be particularly unsafe and have led to serious infections, blindness, and death. "Some of the potential safety concerns include 1) administration site reactions, 2) adverse reactions due to the cell administration procedure, 3) potential unwanted inflammatory and or/immune response to the cells, 3) the ability of the cells to migrate from the site of the administration and differentiate into inappropriate cell types, 5) adverse effects on physiologic function, 6) risk associated with administrative procedures, especially when there is a lack of evidence to show that the cells function as anticipated in the target tissue of the body, 7) excessive pro filiation of the cells in the body, and 8) the development of tumors in the body. ![]()
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